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For patients pairing B12 with NAD+ IV therapy during energy-focused protocols, B12 typically runs weekly between NAD+ sessions and helps sustain the cellular energy benefits between infusions
Gastrointestinal side effects are the primary clinical concern: nausea (44%), diarrhea (30%), vomiting (24%), and constipation (24%) are common, particularly during dose escalation
Moreover, insulin-like growth factor binding protein related proteins (IGFBPrPs) have been recently characterised, which aid the metabolic effects of the hormone but their role remains unclear [96, 97]
Together, they support body recomposition, meaning fat loss with muscle maintenance or even gain
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