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Reported benefits (per available research): Studied for its ability to produce sustained, dose-dependent increases in growth hormone and IGF-1 secretion in a Phase 1 human trial in healthy adults, published by Teichman et al
While the medications are highly effective at reducing appetite and supporting weight loss, experts say many patients unknowingly consume too little protein and too few essential nutrients, increasing the risk of losing lean muscle alongside fat
Due to the negative effects of thiazolidinediones on bones (29) and fluid retention which would add to the ones of hypercortisolism metformin either as monotherapy or, if glycemic targets cannot be reached, in combination with other oral antidiabetic drugs, GLP-1 receptor agonists or insulin should be considered as first choice
