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Cardiovascular and Kidney Outcomes and Mortality With Long-Acting Injectable and Oral Glucagon-Like Peptide 1 Receptor Agonists in Individuals With Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Trials
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The measures included: Appendicular and trunk fat-free mass (proxy for lean muscle) Whole-body and trunk fat mass Body-fat percentage Waist-to-hip ratio Key Findings The researchers found that for every 1-unit reduction in BMI linked to GLP-1 mimicry: Fat mass decreased by ~7.9 kg Lean mass (muscle) decreased by ~6.4 kg Body-fat percentage dropped by ~4.5% In other words, fat loss exceeded muscle loss in both absolute and relative terms, which supports the use of GLP-1 drugs as a viable treatment for obesity
Laboratory research record on GLP-1S [PMID: 38647981] PubMed laboratory record discussing GLP-1S in a research context
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