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CJC1295 (no DAC) often requires more frequent injections to maintain its effect, while CJC1295 with DAC may be dosed about once per week due to its longer halflife

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16,27 Steroidal MRAs (e.g., spironolactone and eplerenone) carry a Class 2a recommendation in both the AHA and JCS/JHFS guidelines and may reduce HF hospitalizations in selected subsets of patients with HFpEF, whereas the European Society of Cardiology (ESC) guidelines do not provide specific recommendations for their use in this population