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Based on these findings, we conclude that hydroquinone in concentrations above 4% and in treatment courses longer than 3 months may be associated with new-onset ochronosis

Neurology 97, 280289

Others are popular online with very thin clinical evidence specific to the knee

Probiotics (link to my probiotic article) for rebuilding your gut flora, aka microbiome, and taking on the bad bacteria, which can be the cause of many of our issues

75 In breast and ovarian cancers, for instance, hypomethylation of the ABCB1 (MDR1) promoter correlates with its overexpression, leading to elevated P-gp levels and enhanced efflux of chemotherapeutic agents, culminating in MDR