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This HO-1-dependent cytoprotective mechanism may explain much of BPC-157s observed ability to protect cells against ischaemia-reperfusion injury and oxidative damage across multiple tissue types simultaneously

Ultrastructurally, three types of cytoplasmic inclusions have been described: dense reticulated substance in the dilated cisternae of rough endoplasmic reticulum, fine granular substance in rough endoplasmic reticulum, and nonmembrane bound dense granulofibrillar in the cytoplasm (Helyer and Petrelli 1978)

The work was also supported by the South-Eastern Norway Regional Health Authority

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The downsides are significant