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We kept the animals in the animal experiment center (SPF-grade) of Huazhong University of science and technology (22C2C, 12 h light/dark cycles, 40%60% humidity)

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Combination with premix insulin 12 oral antidiabetic medicinal products On week 30 of the trial (see Subsection Assessment of Effect on CVS) a subset of 867 patients on therapy with premixed insulin (with or without 12 oral antidiabetic medicinal products) was evaluated