Additionally, electrophysiological experiments have shown the direct effects of B vitamins on pain transmission pathways in the spinal cord and thalamus, which explains the observed reduction or loss of pain sensation in clinical patients
People taking high-dose B12 supplements (1,000 to 5,000 mcg daily), receiving B12 injections (cyanocobalamin or methylcobalamin), or consuming heavily fortified foods can easily push their serum levels above 900 pg/mL
Vitamin B12 Deficiency The exact prevalence of Vitamin B12 deficiency remains unknown, but recent studies estimate between 1% and 20% of American adults have lower than optimal levels
" Patients negative for intrinsic factor antibody, with no other cause of deficiency, may still have pernicious anaemia and should be treated as anti-intrinsic factor antibody negative pernicious anaemia
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