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3.4 Efferocytosis-derived MCTRs metabolically promote sustained macrophage efferocytosis via Rac1-mediated glycolytic activation The continuous engulfment of multiple apoptotic cells by phagocytes is crucial for maintaining organ function, resolving acute inflammation, and facilitating tissue repair

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An arginine replaces glutamic acid at position 3 and a 13-amino-acid extension is added to the N-terminus, which substantially reduces binding to IGF-binding proteins and extends the plasma half-life compared to native IGF-1