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Why Is the FDA Making This Change

Conclusions AS is a complex disease, which makes characterizing its underlying mechanisms difficult

Burak Altintas, MD, an orthopedist with UTMB, who was not involved in this study, further highlighted the following limitations of the research: The limitations include retrospective design and likely residual confounding despite matching as fracture risk is influenced by many variables that are not reported [] Further, the comparison group is heterogeneous, combining another GLP-1 receptor agonist (dulaglutide) with two mechanistically different weight-loss medications

Faster is not automatically better

Most patients notice changes within 2-3 months of starting treatment, often coinciding with the first 5-10% weight loss