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The rs4680 variant affects COMT's activity, with the variant A allele producing an enzyme with 40% lower activity than the ancestral G allele

Nutritional priorities to support GLP-1 therapy for obesity: a joint advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society

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Brain Res 526 : 108112 Bell JG, Sargent JR, Tocher DR, Dick JR

Patients taking Zepbound should be educated on specific symptoms and situations that warrant immediate medical attention or prompt consultation with their healthcare provider