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Hormones such as glucagon-like peptide-1, leptin, ghrelin, and CCK not only regulate appetite and energy balance but also directly influence taste receptor expression and function in the tongue and gastrointestinal tract

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A couple of other drugs (the anticonvulsant topiramate, and bupropion on its own) have weight-reducing tendencies and are occasionally used off-label, though neither is approved for weight management as a standalone treatment in Canada