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GH-mediated changes are slow, meaningfully slower than testosterone or GLP-1 results, because they work through downstream protein synthesis and tissue remodeling

To put it into perspective, for someone weighing 240 lbs, this translates to an average loss of 33 lbs with Semaglutide, compared to 48 lbs with tirzepatide

J Nanobiotechnol 23 , 633 (2025)

Report vision changes, severe abdominal pain, or signs of allergic reaction (rash, difficulty breathing) to a medical professional immediately

All of these GLP-1 effects (Figure 2) are potentially beneficial for patients with T2D, and have been sought exploited clinically with the development of GLP-1R agonists