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Extracellular turnover of free coenzyme A can proceed via dephosphorylation to 3-dephospho-CoA or via hydrolysis yielding 3-phosphoadenosine 5-phosphate (PAP) and 4-phosphopantetheine

Trehalose, a natural disaccharide, has also been proposed as a possible therapy for FTLD as it can restore wild type levels of progranulin expression in Prgn haploinsufficient mice [66]

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Its key component, glutathione, is a potent natural antioxidant produced by cells