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It's about being the right tool for the right job

Recent studies show pancreatic intra-islet GLP-1 expression, which is regulated by cytokines, hyperglycemia and cell injury

Exploratory analyses revealed exenatide significantly reduced heavy drinking days and total alcohol intake in a subgroup of obese patients. Senior author Professor Anders Fink-Jensen told medscape.com: Something is happening in the brain, and activation of the reward centre is hampered by the GLP-1 compound. And he noted: If patients with AUD already fulfill the criteria for semaglutide (or other GLP-1 analogs) by having type 2 diabetes and/or a Body Mass Index (BMI) over 30kg/m2, they can of course use the compound right now. Professor Fink-Jensens team is also beginning a study in patients with AUD and a BMI greater than 30 kg/m2 to investigate the effects on alcohol intake of semaglutide up to 2.4 mg weekly (the maximum dose currently approved for obesity patients in the US)

88 The proton gradient drives the translocation of protons from the intermembrane space (IMS) to the matrix via ATP synthase (Complex V), which catalyzes the conversion of ADP to ATP

Acknowledgements The authors are indebted to Dr