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PAB rats at both time points showed significant pathology compared to Sham, including RV dilation and dysfunction, which were recorded as increased right ventricular end-diastolic area (RVEDA), and decreased right ventricular fractional area change (RVFAC) and tricuspid annular plane systolic excursion (TAPSE)

Based on typical prescribing patterns, two vials are designed to last approximately 2 months

The increase of intracellular ROS is believed to correlate with the activation of nuclear factor (NF)-kappa B, a transcription activator linked to the elaboration of several cytokines (Figure 6)

For a 2.5 mg target dose: Volume to Draw = Desired DoseConcentration = 2.5 mg10 mg/mL = 0.25 mL Convert to syringe units

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