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J Biol Chem (2018) 293:10895910
There is no trial data establishing an optimal duration for MOTS-c, so that range comes from clinical practice and pharmacologic reasoning rather than from published head-to-head comparisons
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Finally, if the serum cobalamin concentration at the time of reevaluation is subnormal [lower than normal], further work-up is required to definitively diagnose the underlying disease process and cobalamin supplementation should be continued weekly or bi-weekly
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