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did not observe significant differences in amputation risk between GLP-1 receptor agonists, SGLT-2 inhibitors, and other diabetes medications in a large retrospective cohort study of 1,222,436 patients with type 2 diabetes
All significantly regulated regions among the preselected 12 regions as well as the 800+ regions went through statistical validation, in which the model deviance residuals were investigated to determine whether they aligned with the assumptions of normality and homoscedasticity
Dubois-Deruy E, Peugnet V, Turkieh A, Pinet F