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Experimental studies have explored its effects in models involving soft tissue injury, gastrointestinal function, vascular biology, and musculoskeletal recovery

All the statistical analyses were performed with GraphPad Prism 10.0 (GraphPad, Inc.)

In summary, the reprogramming of hepatocytes associated with a profibrotic milieu results in loss of mature parenchymal cells, characterized by loss of the master hepatocyte transcription factor HNF4 (158, 212) and upregulation of the developmental Notch, Hippo (213), and Hedgehog (214) signaling pathways

GH is the primary driver of tissue repair and protein synthesis