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[5] Lochhead, J.J., & Thorne, R.G

In particular, it has been shown to reduce immediate allergic reactions and thermal hyperalgesic responses in sensitized animals

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Most of these involve the stifle (knee) joint, where the cranial cruciate ligament, menisci, and articular cartilage work together and where the majority of canine orthopedic injuries occur: Cranial Cruciate Ligament Disease: The canine equivalent of human ACL tears, extremely common in medium to large breeds