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The review highlights sustained hyperinsulinemia as a key driver of obesity- and T2D-related cancer risk and notes that GLP-1RA-mediated reductions in insulin could partly explain the observed benefits
Maintaining a healthy immune system and preventing metal and drug poisoning
The different ones GI discontinuation rate: 5.6% of semaglutide (Wegovy) users stopped due to GI side effects, vs 2.7% of Tirzepatide (Mounjaro) users Diarrhoea: Common with Mounjaro because of its dual action Nausea and constipation: Seen more in Wegovy MHRA NAION warning (February 2026) : Both medications carry an updated warning about a very rare but serious eye condition (non-arteritic anterior ischaemic optic neuropathy)
However, if the pain originates from actively dying small nerve fibers in the skin, treatments must address the local inflammation, autoimmune attacks, and vascular issues driving that nerve death
