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While DKA is rare with GLP-1 receptor agonists, cases have been reported, particularly when concomitant insulin is rapidly reduced or discontinued
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The article adds that combined use has not been systematically studied for drug-drug interactions or cumulative adverse event rates, which is why it calls for extra clinical caution
This means compounding pharmacies, which create customized versions, must stop by April 22, 2025, for state-licensed (503A) and May 22, 2025, for outsourcing facilities (503B), unless a court rules otherwise
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