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Improved survival for children and young adults with t-lineage acute lymphoblastic leukemia: results from the children's oncology group AALL0434 methotrexate randomization
Despite the negative results observed, since 2005 to date, more than a dozen of AAAs entered in clinical trials, but most of these trials terminated unsuccessfully and with no FDA approval
By sustaining appropriate DNA methylation, SAMe has a broad range of potential effects on cell repair, inflammatory mediator release, and the pathobiology of ongoing immune-mediated liver injury
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