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In diabetic nephropathy, podocyte NOX4derived HO drives podocyte injury and slit-diaphragm defects, thereby promoting albuminuria [345], whereas in diabetic retinopathy PKC-driven and VEGF-driven permeability changes are tightly linked to oxidative stress [346]

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While not typically life-threatening, your body may experience a range of withdrawal symptoms that can be very uncomfortable

Biosci Biotechnol Biochem 58(5):878880 Koontz L (2014) TCA precipitation