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Interestingly, at the age of 47 years P20 developed extensive surgical emphysema within the subcutaneous tissues of her face and computed tomography (CT) scans of the sinuses revealed a defect of the left nasal cartilages anteriorly allowing air to track into the soft tissues

doi:10.1155/2024/8827402

Titration: Increase by ~200 mcg every 2 weeks: 400 mcg (Weeks 34), 600 mcg (Weeks 56), 800 mcg (Weeks 78)

This was the first real step in a long regulatory process not the finish line

You may need to rest in bed and avoid triggers for the rest of the (or days), which can be difficult if you have a busy or active lifestyle