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Mild and temporary side effects were reported

Research has demonstrated that B12 supplementation in deficient individuals can significantly reduce fatigue and improve physical performance

This stimulates the synthesis and release of endogenous growth hormone. Growth hormone subsequently acts on the liver and other peripheral tissues, increasing: Insulin-like growth factor 1 Insulin-like growth factor binding protein 3 GH-dependent metabolic signaling Lipolytic and tissue-remodeling pathways In the Phase 3 studies, mean IGF-1 increased substantially during the initial 26-week treatment period

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