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That's the whole variable

The observed increase in RelB likely contributes to the increased expression of chemokines (Ccl2, Ccl4, Ccl20, Cxcl2, and Cxcl10) in the liver [295]

Cyclic nucleotides are involved in major intracellular signaling pathways that modulate various physiological processes such as signal transduction, synaptic transmission, and hormonal regulation (Giembycz and Maurice, 2014

Interestingly, they also caused significant weight loss, mostly through effects on the brain that help control hunger and fullness. This finding is why they were developed as weight loss medications

However, the larger ACT trial (n=2,308) did not confirm this benefit (ACT Investigators, Circulation, 2011) [68]