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Cancer Med 2018;7:107080.ArticlePubMedPMCPDF 5
[2] [5] The most commonly reported side effects of tirzepatide are gastrointestinal in nature, occurring in a substantial proportion of patients during clinical trials
The FDAs current safety page continues to cite concerns about immunogenicity, peptide impurities and limited safety data, and the agency has stated that a substance may still pose significant safety risks
Alternatively, the same active ingredient, semaglutide, is produced as oral Rybelsus, which is approved for Type 2 diabetes mellitus
Summary: Retatrutide is an investigational triple receptor agonist (GLP-1, GIP, and glucagon) showing promising early evidence for significant weight reduction, improved metabolic markers, and reduced liver fat, but it has not yet received MHRA or EMA approval
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