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Recently, using chimeric receptors, we have demonstrated how domain differences between IR and IGF1R contribute to the distinct functions of these receptors (14)

50 weeks of intervention has beneficial effects on decreasing HOMA-IR, HbA1c, and FBG

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The 4-substituted benzyl chain formed a hydrophobic bond with F424 and F427, while the C3-(4-fluorophenyl) amino side chain occupied a lipophilic pocket made up of F392, L409, and V417 (Figures 7A,B)