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If switching from tirzepatide to retatrutide, start retatrutide at 2 mg regardless of your previous tirzepatide dose and titrate up on the standard schedule
The endogenous intestinal GLP-1 sequence corresponded to a truncated form of GLP-1, formed by a monobasic cleavage between residues 77 and 78 in proglucagon, resulting in an amidated peptide with the full sequence of PG 78106 amide [29]
306 For example, the reduction in TNF-, IL-1, and IL-6 helps regulate local and systemic inflammatory responses
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