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Yes, refrigerating an opened vial at 2 to 8C is acceptable and will not damage it

Always use proper sterile technique and discard any reconstituted solution that appears cloudy or develops visible particles

You can find further information on vitamin B12, the other micronutrients from the vitamin B group, and deficiencies, in the health field - Vitamin B deficiency

Quality verification becomes even more important when combining compounds, since impurities or inaccurate dosing in one product amplify risks when another compound is added to the protocol