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Switching from Injectable to Oral# Recommendation : Orforglipron Reason : ATTAIN-MAINTAIN showed that patients switching from injectable semaglutide or tirzepatide to oral orforglipron maintained their previously achieved weight loss, validating oral step-down therapy

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Process-Induced Modifications and Regulatory Compliance GLP-1 peptides degrade or transform through multiple routes, creating a complex impurity profile that must be tracked for regulatory compliance

Upon infusion, GLP-1 exerts potent vasodilatory effects on conduit artery and arterioles in healthy humans leading to increased blood flow for enhanced microvascular recruitment and muscular perfusion 46

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