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CLINICAL PRACTICE CONSIDERATIONS Long-term outcomes While strong evidence supports the kidney-protective effects of both SGLT2 inhibitors and GLP-1 receptor agonists, the long-term durability of these benefits remains uncertain (Table 2)

This form of Zepbound comes in a vial, which means patients must use a disposable syringe to inject it, rather than a self-injectable pen

Both peptides bind to the Growth Hormone Secretagogue Receptor type 1a (GHS-R1a) on pituitary somatotropes, triggering pulsatile GH release

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Data analysed by one-way ANOVA, multiple comparison, Bonferroni post hoc test ( e , f , k and l ) and two-way repeated measures ANOVA to assess main effects of treatment ( b , d , h - j , n and p )