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scRNA-seq of peripheral blood mononuclear cells (PBMCs) from patients with ABMR has mapped the transcriptomic landscape, highlighting strong interactions between T/B cells and neutrophils in ABMR pathogenesis (10), A single human kidney allograft biopsy with mixed rejection showed complex immune cell infiltrates and proinflammatory responses in parenchymal cells (11)

As our understanding of glucocorticoid-related metabolic dysregulation evolves, therapies targeting the underlying pathophysiological mechanisms offer significant advantages beyond glucose lowering alone

4.2.2 Regulating autophagy Autophagy is a key homeostatic pathway that facilitates the degradation and recycling of cellular material [69]

& Holzhausen, H

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