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In cancer cells, DRP1-mediated mitochondrial fission induces cytosolic mtDNA stress to enhance the CCL2 secretion from cancer cells via the TLR9-mediated NF-B signaling pathway, which promotes M2 polarization [330]

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A nano-lipid GHK formulation produced a 31.6% reduction in wrinkle volume at 8 weeks in a separate human trial (Pickart & Margolina, 2018)

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