Key finding: Ipamorelin produced GH release without the significant appetite stimulation seen with GHRP-6 , confirming its unique selectivity advantage for body composition research
Excess fat in this area is linked to numerous problems ranging from heart disease to insulin resistance and fatty liver disease
There are also several proposed direct renal effects including 2 , 3 , 8 : 1) Reduced intraglomerular pressure by activating tubuloglomerular feedback (TGF) on the basis of acute proximal tubular natriuresis 9 - 12 leading to afferent arteriolar vasoconstriction, particularly in the setting of renal hyperfiltration 13 - 19
reports research funding, advisory/consulting fees and/or other support from AstraZeneca, Bausch Health Inc., Boehringer Ingelheim, CIHR, Janssen, Eli Lilly & Company and Novo Nordisk
The glucagon component may affect hepatic metabolism, energy expenditure and the mobilisation of stored energy