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Genistein is the main ingredient of isoflavone from soybean and is also used as a tyrosine kinase inhibitor
High doses reaching 400 micrograms can even be harmful
Strongest human evidence The METAOD006 (OPTIONS) Phase 2b trial randomized 502 adults with obesity (BMI 30-45 kg/m^2) to oral AOD-9604 (0.25, 0.5, or 1 mg/day) or placebo for 24 weeks alongside a supervised diet and exercise program
Because Cyclospora will not grow in culture, investigators had no clean genetic fingerprint to match cases across states, so they relied on good ol interviews and shipping records
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