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As a triple receptor agonist (GIPGLP-1GCG) , Retatrutide targets multiple pathways involved in hunger and metabolism: GIP (Gastric Inhibitory Polypeptide) An incretin hormone released after eating that stimulates pancreatic beta cells to secrete insulin

The medication acts on appetite centres in the hypothalamus, reducing hunger and increasing satiety

The most common adverse events, affecting over 20% of participants, included skin hyperpigmentation, nausea, vomiting, and headache

2019;3(12):nzz120

Insufficient for melanogenesis inhibition, which requires sustained concentrations above 15 mol/L according to in vitro tyrosinase assay data