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Tirzepatide also affected proteins involved in neurotransmission, such as solute carrier family 6 member 6 (SLC6A6), reticulon 3 (RTN3), proline-rich transmembrane protein 2 (PRRT2), alpha-aminoadipic semialdehyde synthase (AASS), and microtubule-associated protein 1A (MAP1A)
Patients who are already sleeping well, training consistently, and managing weight typically see less dramatic early changes but better long-term composition results
Diabetic peripheral neuropathy remains the most common cause of numbness and tingling in individuals with type 2 diabetes, affecting a substantial proportion of patients during their disease course
Some patients respond better to one over the other
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