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(PubMed) The same review warns that systemic administration (IV) may shift melanin production, altering skins natural photoprotection and potentially increasing the risk of UV-induced skin damage or cancer a risk especially relevant in sunny climates

Treated wounds contracted at least 11% more than controls by day 7, with increased collagen deposition and angiogenesis confirmed histologically

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Molecular Biology of Methylenetetrahydrofolate Reductase (MTHFR) and Overview of Mutations/Polymorphisms Austin (TX): Landes Bioscience