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It is normally conjugated by glutathione (GSH), but when taken in excess, the body's glutathione reserves are not sufficient to deactivate the toxic NAPQI

It is the predominant intracellular non-protein thiol in mammalian tissues, present at concentrations typically ranging from 110 mM in the cytosol, with particularly high concentrations in the liver (up to 10 mM), which is the primary site of GSH synthesis and export

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A practical checklist looks like this: Build meals around protein: this helps preserve lean tissue and supports steadier glucose handling