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[5] [6] Early-phase clinical trials including a Phase 2 trial published in the New England Journal of Medicine (2023) have reported significant reductions in body weight and improvements in metabolic markers, though this evidence remains preliminary and is not sufficient to establish a clinical dosing or reconstitution standard

This metabolic neutrality is precisely why they combine well

Because effect sizes vary by indication, dosing, individual factors, and adherence, a thoughtful provider frames frequency as something to reassess rather than fix permanently

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In those cases, the data may still be scientifically useful, but it should not be described as exclusively NNMT-mediated without additional evidence