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Integrative hallmarks emerge when accumulated damage and stress responses begin to overwhelm the body's repair systems
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Echinocandin resistance is primarily driven by mutations in FKS1 , while drug-induced cell wall stress can activate tolerance pathways such as the Ca + /calcineurin and Hsp90/mTOR signaling cascades (Perlin, 2007
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Andy Hsieh, a biotech analyst at the investment bank William Blair, says his initial reaction upon seeing Novo Nordisks findings was, Oh man
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