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The relatively short half-life, compared with longer-acting compounds in the broader GH-axis class, is part of why Ipamorelin produces a pulsatile, physiologically patterned GH release rather than a sustained elevation, which is one of the reasons it remains a preferred reference tool for studying pulsatile GH secretion patterns

However, a retrospective cohort study published in Diabetes Care did find that use of GLP-1 medications for 1-3 years was associated with a slightly increased risk of all thyroid cancer (adjusted hazard ratio 1.58) and medullary thyroid cancer specifically (adjusted hazard ratio 1.78)

Weight Loss Plateaus A weight loss plateau happens when progress stalls despite continued effort

Kim DD, Basu A

In clinical trials for Wegovy, people who changed their diet and exercise patterns lost an average of 14.9% of their body weight in 68 weeks