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DEP domain containing 5 (DEPDC5) deficient CD8 + T cells exhibit spontaneous ferroptosis due to mTORC1-induced Activating Transcription Factor 4(ATF4) upregulation, leading to elevated xanthine oxidase activity and lipid ROS accumulation [92]
Smoking There are a lot of free radicals in cigarette smoke, which makes oxidative stress much worse
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Experimental observations suggest FOXO4-DRI could be relevant for exploring how proteasomal function might be preserved in cardiac tissues, with implications for studying age-associated heart conditions
