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Patients with a history of pancreatitis require careful assessment before starting treatment

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"Reductive stress" refers to a condition within a cell where there is an abnormal accumulation of reducing equivalents, like NADH or glutathione, exceeding the cell's ability to oxidize them, leading to disruptions in cellular functions and potentially causing damage, similar to how oxidative stress occurs due to an excess of oxidizing agents

Patients with irregular schedules preventing consistent morning dosing, cognitive limitations affecting complex medication routines, or lack of understanding about administration requirements may be directed toward injectable alternatives with simpler once-weekly protocols

Bax, Bcl2 and p53 differentially regulate neomycin- and gentamicin-induced hair cell death in the zebrafish lateral line