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Notably, despite the presence of severe obesity, large-scale population cohort studies have revealed that individuals with MC4R -deficient obesity exhibit a unique metabolically protective phenotype
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Ubiquitin proteasome-dependent degradation of the transcriptional coactivator PGC-1 via the N-terminal pathway
refrigeration at 4 C (39 F) is acceptable for short-term storage (days to weeks)
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