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The downstream signaling cascade follows the PI3K/Akt/mTOR pathway
Its bioavailability is somewhat improved over that of ordinary GSH, but remains limited
Additionally, extreme weight loss or low body weight can result in amenorrhea, the absence of menstruation, due to hormonal imbalances that suppress ovulation
Research demonstrates reduced adipocyte lipid accumulation and increased basal metabolic rate without feeding-behavior changes
By contrast with the rat, the mouse exhibits high constitutive levels of GST activity towards AFB 1 -8,9-epoxide and alpha-class GST in Swiss-Webster mice possess high activity towards AFB 1 -8,9-epoxide and can protect against DNA-binding by AFB 1 metabolites
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