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In the U.S., CMS guidance from March 2024 allows Medicare Part D coverage of AOMs with medically accepted indications, such as diabetes or reducing the risk of major adverse cardiovascular events in patients with established cardiovascular disease

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Common side effects include gastrointestinal symptoms such as nausea, diarrhoea, and abdominal discomfort, particularly during initial treatment

Researchers who combine tirzepatide with cardio endurance peptides or athletic performance compounds often report that the energy gains at this stage exceed their pre-treatment baseline

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