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| Take home message According to data from two randomised controlled trials (STEP 1 and SUSTAIN 8), up to 40% of the weight lost on semaglutide (Wegovy/Ozempic) may be from lean mass

A compound that has been degraded through poor storage, inadequately purified, or incorrectly dosed produces results that do not reflect what the research literature documents

Furthermore, as antioxidant rescue experiments were not performed in this study, the observed ROS accumulation remains an associated phenomenon rather than a proven causal mediator of cell death